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Posted on: February 1, 2009

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ALBENZA is indicated for the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the,.
IMPORTANT NOTE: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your health care professional. Always seek the advice of your health care professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. This information does not contain any assurances that this product is safe, effective, or appropriate for you.
Dosage is based on your weight, medical condition, and response to treatment. Take this medication exactly as prescribed by your doctor. Some conditions may require you to stop the medication for 2 weeks and then restart the medication. If that is the case, it may be helpful to mark the calendar with a reminder of when you need to restart the medication.
Patients being treated for neurocysticercosis should receive appropriateandtherapy as required. Oral orcorticosteroids should be considered to preventepisodes during the first week of treatment.
Patients with Impaired Renal Function:The pharmacokinetics of albendazole in patients with impaired renal function have not been studied. However, since renal elimination of albendazole and its primary metabolite, albendazole sulfoxide, is negligible, it is unlikely that clearance of these compounds would be altered in these patients.

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Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088. In Canada, you may call Health Canada at 1-866-234-2345.

Geriatric Use

Absorption and Metabolism:Albendazole is poorly absorbed from thedue to its low aqueous solubility. Albendazole concentrations are negligible or undetectable in plasma as it is rapidly converted to the sulfoxide metabolite prior to reaching the systemic circulation. The systemic anthelmintic activity has been attributed to the primary metabolite, albendazole sulfoxide. Oral bioavailability appears to be enhanced when albendazole is coadministered with a fatty meal (estimated fat content 40 g) as evidenced by higher (up to 5-fold on average) plasma concentrations of albendazole sulfoxide as compared to the fasted state.
The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

Microbiology

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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